The aim of every biospecimen resource should be to collect, maintain, and disseminate the highest quality biospecimens, based on the intended research use. High-quality biospecimens are defined as those whose biology most closely resembles the biology of the biospecimen prior to its removal from the human research participant. Once the biospecimen is collected (and sometimes prior to its removal) the biospecimen may begin to take on new characteristics based on changes to the biospecimen’s environment; e.g., changes in exposure to certain nutritional, chemical, or other environmental factors that may occur during a surgical or collection procedure. Such changes may result in inaccurate determinations of the molecular and physical characteristics of the biospecimen during subsequent analysis. Every attempt should be made to minimize the effects of biospecimen handling on biospecimen integrity.